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Abstract: A novel strategy for anti-HIV therapy is the clearance of the residual infected cells from the body. Here, we show that 6-aminopurine, adenine, induced selective apoptosis toward HIV-1 producing chronically infected MOLT4 cells (MOLT4/HIV) without augmentation of virus production, whereas the growth of uninfected MOLT ...
http://www.aegis.org/aidsline/2000/nov/a00b0433.html
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Abstract: Modeling studies, combined with the molecular docking of the trinucleotide GGG into the active site of the deadenylating RNA N-glycosidase pokeweed antiviral protein (PAP), indicated that a guanine base can fit into the active site pocket of PAP without disturbing its unique geometry and is sandwiched between residues ...
http://www.aegis.org/aidsline/1999/dec/a99c0077.html
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Abstract: We have reviewed the results of treating over 100 HBV carriers with adenine arabinoside, adenine arabinoside monophosphate and lymphoblastoid interferon. In the homosexual group of carriers, adenine arabinoside and its monophosphate have no value. However, in this group, lymphoblastoid interferon will produce a respon ...
http://www.aegis.org/aidsline/1987/oct/m87a0166.html
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Abstract: Crystal structure of a DNA.RNA hybrid, d(CTCCTCTTC).r(gaagagagag), with an adenine bulge in the polypurine RNA strand was determined at 2.3 A resolution. The structure was solved by the molecular replacement method and refined to a final R-factor of 19.9% (Rfree 22.2%). The hybrid duplex crystallized in the space grou ...
http://www.aegis.org/aidsline/2000/sep/a0090881.html
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Abstract: We have investigated the molecular basis of the 100-fold resistance of mutant human erythroleukemia K562/PMEA-1 cells to the antiproliferative potential of 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Upon exposure to high PMEA concentrations, comparable intracellular PMEA levels were initially observed in mutant K562/ ...
http://www.aegis.org/aidsline/1999/feb/a9920280.html
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Abstract: We assessed the effects of hydroxyurea (HU) at a concentration of 50 microM on the in vitro activities of 2 ,3 -dideoxyinosine (ddI), 9-[2-(phosphonylmethoxy)ethyl]adenine (PMEA), and 9-[2-(phosphonylmethoxy)propyl]adenine (PMPA) against a wild-type human immunodeficiency virus (HIV) type 1 (HIV-1) laboratory isolate ...
http://www.aegis.org/aidsline/1999/nov/a99b0592.html
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Abstract: 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its closely related structural analogue (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) are potent inhibitors of retroviruses and hepatitis B virus. In its oral prodrug form (adefovir dipivoxil), PMEA is currently the subject of advanced phase II/III clinical trials for t ...
http://www.aegis.org/aidsline/1998/dec/m98c6474.html
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Abstract: New nucleoside analogues 14-17 based on a methylenecyclopropane structure were synthesized and evaluated for antiviral activity ...
http://www.aegis.org/pubs/medline/1998/jan/m9819932.html
File Name: m9819932.html, Size: 8KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
Abstract: Recent experiments have shown that difluorotoluene (F), a nonpolar isostere for thymine (T), codes efficiently and specifically ...
http://www.aegis.org/pubs/medline/1998/jan/m9817131.html
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Abstract: From a side-by-side comparative study, the acyclic nucleoside phosphonates (R)-9-(2-phosphonylmethoxypropyl)adenine [(R)-PMPA] and 9-(2-methylidene-3-phosphonomethoxypropyl)guanine (MDL 74,968) proved more selective in their inhibitory effect on human immunodeficiency virus types 1 and 2, feline immunodeficiency virus ...
http://www.aegis.org/aidsline/1997/aug/m9780853.html
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Abstract: 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), an acyclic nucleoside phosphonate analog, is active against several retroviruses and herpesviruses and has shown anti-human immunodeficiency virus (HIV) activity in clinical trials. Serial passage of HIV type 1 (strain IIIb, in MT2 cells in increasing concentrations of PMEA ...
http://www.aegis.org/aidsline/1997/apr/m9740999.html
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Abstract: to study the possible relation among adenine accumulation, guanine to adenine hypermutation and RNA secondary structure in HIV-1 genomes. <p><b>METHODS</b>: Fifteen HIV-1 and one HTLV-I sequences were obtained from Los Alamos data base. RNA folding (secondary structure) was predicted by using the FOLD program with up ...
http://www.aegis.org/conferences/iac/1996/moa1011.html
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Abstract: Z) and (E)2-hydroxymethyl)cyclopropylidene)methyladenine and guanine. New nucleoside analogues with a broad-spectrum antiviral activity.J Med Chem. 1998 Jan 1;41(1)10-23. Unique Identifier : AIDSLINE MED/98100829 Qiu YL; Ksebati MB; Ptak RG; Fan BY; Breitenbach JM; Lin JS; Cheng YC; Kern ER; Drach JC; Zemlicka ...
http://www.aegis.org/aidsline/1994/apr/m9840742.html
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Abstract: Hydroxyurea (HU) increases the action of other anti-HIV drugs - even against viral strains resistant to those drugs, a new study suggests. ...
http://www.aegis.org/pubs/aidswkly/1999/aw990807.html
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Abstract: The main advantage of the use of electrochemical methods is that the object studied is under conditions very close to the natural ones. Next advantage is that the same information about the sample can be received with lower costs than other methods. The electrode double layer impedance measurement is effective electro ...
http://www.aegis.org/aidsline/2000/jul/a0070380.html
File Name: a0070380.html, Size: 9KB, Last Modified: Friday, July 28, 2000 at 8:12:04 PM
Abstract: (R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA) is an acyclic nucleoside phosphonate that has been shown to be effective in the treatment of AIDS although it has a shorter separation between the adenine and phosphorus than dideoxy-AMP and dAMP. By using pre-steady state kinetic methods, we examined the incorporation o ...
http://www.aegis.org/aidsline/1999/jan/a9910626.html
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Abstract: 9-[(2R,5R-2,5-dihydro-5-phosphonomethoxy)-2-furanyl]adenine, or D4API, was tested in the feline immunodeficiency virus (FIV) infection model and found to be significantly more inhibitory in vitro than its parent compound 9-phosphonylmethoxethyl adenine PMEA). Cytotoxicity was less than for PMEA or azidothymidine ...
http://www.aegis.org/aidsline/1998/jan/m9810055.html
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Abstract: Lipophilic ester prodrugs of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), i.e., bis(pivaloyloxymethyl)-PMEA [bis(POM)-PMEA] and diphenyl-PMEA, have been synthesized in an attempt to increase the oral bioavailability of this broad-spectrum antiviral agent. The antiretroviral efficacy was determined in severe combined im ...
http://www.aegis.org/aidsline/1997/mar/m9730010.html
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Abstract: Objective: to study the possible relation among adenine accumulation, guanine to adenine hypermutation and RNA secondary structure in HIV-1 genomes. Methods: Fifteen HIV-1 and one HTLV-I sequences were obtained from Los Alamos data base. RNA folding secondary structure) was predicted by using the FOLD program with upd ...
http://www.aegis.org/aidsline/1997/jan/m9716105.html
File Name: m9716105.html, Size: 10KB, Last Modified: Tuesday, January 28, 1997 at 8:12:04 PM
Abstract: 9-(2-Phosphonylmethoxyethyl)adenine (PMEA), the acyclic phosphonate analog of adenine monophosphate, is a promising antiviral drug with activity against herpesviruses, Epstein-Barr virus, and retroviruses, including the human immunodeficiency virus. In order to be active, it must be converted to the diphosphate deriva ...
http://www.aegis.org/aidsline/1996/aug/m9680731.html
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Abstract: The (S)- and (R)-enantiomers of 9-(2-phosphonylmethoxypropyl) derivatives of adenine (PMPA) and 2,6-diaminopurine (PMPDAP) were evaluated for their inhibitory effect on HIV replication in several human cell systems, including natural peripheral blood lymphocytes (PBL) and freshly isolated monocyte/macrophages (M/M). T ...
http://www.aegis.org/aidsline/1996/jul/m9670295.html
File Name: m9670295.html, Size: 9KB, Last Modified: Sunday, July 28, 1996 at 8:12:04 PM
Abstract: 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is the prototype compound of a series of acyclic nucleoside phosphonate derivatives endowed with potent and selective anti-retroviral activity in vitro and in vivo. We have now found that PMEA is also a potent inducer of differentiation of a number of tumor cells, including h ...
http://www.aegis.org/aidsline/1995/jul/m9570660.html
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Abstract: 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a new antiviral agent with activity against herpes viruses and retroviruses, including human immunodeficiency virus, but its metabolism and mechanism of action remain unclear. We have isolated a human T lymphoid cell line (CEMr-1) that is resistant to the antiproliferative ...
http://www.aegis.org/aidsline/1995/jun/m9560981.html
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Abstract: Four isomeric benzo[a]pyrene-deoxyadenosine adducts, corresponding to the products of trans opening of the epoxide ring in the four configurationally isomeric benzo[a]pyrene dihydrodiol epoxides by the amino group of deoxyadenosine, were separately introduced into each of two 16-mer sequence contexts. The sequences we ...
http://www.aegis.org/aidsline/1995/feb/m9520092.html
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Abstract: The design, synthesis, and biological evaluation of several unsaturated acyclonucleosides related to augustmycin A are described. The (propargyloxy)methyl acyclonucleoside analogues of 6-chloropurine, adenine, 6-methoxypurine, hypoxanthine, 6-mercaptopurine, and azathioprine have been prepared. The 9-[(propargyloxy)me ...
http://www.aegis.org/aidsline/1992/aug/m9280613.html
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Abstract: OBJECTIVE--To synthesize and study the anti-HIV activity of a series of purine nucleoside analogues of the novel class of highly potent and specific inhibitors of HIV-1, the 2 ,5 -bis-O-silylated-3 -spiro-substituted (TSAO) nucleosides. These compounds showed a remarkable stereospecificity in their antiviral behaviour. ...
http://www.aegis.org/conferences/iac/1992/poa2324.html
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Abstract: Condensation of the 3 -ketonucleoside 4 with diethyl cyanomethylphosphonate by a Wittig reaction afforded, after reduction of the unsaturated branched chain sugar nucleoside 5 with sodium borohydride, a mixture of 9-(2 ,5 -di-O-t-butyldimethylsilyl-3 -C-cyanomethyl-3 -deoxy-beta- D-ribo - and xylofuranosyl) adenines 6 ...
http://www.aegis.org/aidsline/1990/jan/m9010346.html
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Abstract: To evaluate the efficacy of EHNA treatment on viral replication in HIV-1 infected cell lines in vitro. <p><b>METHODS</b>: HIV-1 infected or uninfected H9 cell lines were treated with varying concentrations of erythro-9(2-hydroxy-3-nonyl) adenine (EHNA), an inhibitor of the common Adenosine deaminase (ADA) isozyme(s) ...
http://www.aegis.org/conferences/iac/1989/c609.html
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Abstract: a. Simple Facts Sheet. from the. AIDS Treatment Data Network. hydroxyurea (Hydrea). Hydroxyurea is a 30 year old anticancer drug that may help certain anti-HIV drugs work better. Researchers have been studying hydroxyurea in people with HIV for several years now, with some promising results.How does hydroxyurea work ...
http://www.aegis.org/factshts/network/simple/hydr.html
File Name: hydr.html, Size: 7KB, Last Modified: Sunday, August 20, 2006 at 9:21:11 PM
Abstract: A series of 3 -C-cyano-3 -deoxynucleosides have been synthesized and evaluated as antiviral agents. Reaction of 2 ,5 -bis-O-(tert-butyldimethylsilyl)-beta-D-erythro-pentofuranos- 3 -ulosyl derivatives of uracil, 4-N-acetylcytosine, and adenine with sodium cyanide gave a mixture of epimeric cyanohydrins, which after 3 ...
http://www.aegis.org/aidsline/1989/nov/m89b0483.html
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