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Abstract: Despite significant knowledge of the molecular biology and genetics of adenovirus, no specific antiviral agent has been developed for use in adenovirus infections. This contrasts with the situation in herpes simplex virus (HSV) and human immunodeficiency virus (HIV) infections, in which antiviral agents target specifi ...
http://www.aegis.org/aidsline/1994/mar/m9430676.html
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Abstract: The human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR) sequences were inserted into adenovirus in place of the E1 region. The HIV-1 LTR contained in this recombinant adenovirus responds to trans-activation by tatIII in a HeLa cell line constitutively expressing that HIV-1 gene product. In addition, the ...
http://www.aegis.org/aidsline/1988/sep/m8890124.html
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Abstract: Researchers in the United States have identified an HIV vaccine regimen which elicits potent cellular immunity in non-human primates. ...
http://www.aegis.org/pubs/aidswkly/2003/aw030607.html
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Abstract: The use of adenovirus vectors for gene therapy has been limited by well-defined cellular and humoral immune responses. We have previously shown that adenovirus vectors rapidly induce the expression of the C-X-C chemokine, interferon-inducible protein 10 (IP-10), in vivo. Various first-generation, type 5 adenovirus vec ...
http://www.aegis.org/aidsline/2000/jul/a0070993.html
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Abstract: The identification of adenovirus in tissue can be difficult. In situ hybridization for adenovirus nucleic acids may aid in the demonstration of adenovirus infections. To develop a probe against adenovirus, a 978 bp fragment of DNA containing the VA-I, VA-II, and a portion of the L-1 regions of the adenovirus type 2 ge ...
http://www.aegis.org/aidsline/1992/jul/m9270158.html
File Name: m9270158.html, Size: 9KB, Last Modified: Tuesday, July 28, 1992 at 8:12:04 PM
Abstract: <p><b>BACKGROUND:</b> Substantial research focuses on determining the optimal approaches for eliciting cytotoxic T lymphocyte (CTL) responses against viral infection with particular focus on HIV. Gene delivery-based vaccines appear to be the most effective means for accomplishing this goal </p> <p><b>OBJECTIVE:</b> ...
http://www.aegis.org/conferences/iac/2002/mopea3052.html
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Abstract: OBJECTIVE: Replication-deficient, recombinant adenovirus is used as a carrier for gene transfer, but it is unspecific and the o ...
http://www.aegis.org/pubs/medline/1998/jan/m9811338.html
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Abstract: A case of chronic intestinal infection due to adenovirus type 40 lasting for 13 months in a patient with AIDS is described. Adenovirus particles were detected by electron microscopy in biopsy samples taken from the duodenum 3 months after the onset of diarrhoea. The virus was identified as adenovirus type 40 in stool ...
http://www.aegis.org/aidsline/1997/nov/m97b0423.html
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Abstract: To evaluate the prevalence of adenovirus strains in human immunodeficiency virus (HIV)-positive patients and to investigate their possible role in the onset of diarrhea, a total of 103 stools from HIV-seropositive patients at various stages of infection and 200 stools from sex and age cross-matched control subjects we ...
http://www.aegis.org/aidsline/1995/jul/m9570397.html
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Abstract: Retrovirus infection is normally limited to cells within a specific host range which express a cognate receptor that is recognized by the product of the env gene. We describe retrovirus infection of cells outside of their normal host range when the infection is performed in the presence of a replication-defective aden ...
http://www.aegis.org/aidsline/1995/may/m9550405.html
File Name: m9550405.html, Size: 10KB, Last Modified: Sunday, May 28, 1995 at 8:12:04 PM
Abstract: AIMS: To describe the microscopic appearance of adenovirus infection in the large bowel of human immunodeficiency virus (HIV) positive patients with diarrhoea. METHODS: Large bowel biopsy specimens from 10 HIV positive patients, eight of whom were also infected with other gastrointestinal pathogens, with diarrhoea wer ...
http://www.aegis.org/aidsline/1993/jan/m9310716.html
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Abstract: Adeno-associated virus (AAV) is a nonpathogenic parvovirus which normally requires helper adenovirus or herpes-virus for replication. We examined the growth of AAV type 2 in human lymphocytes and its possible interaction with HIV-1. Three B cell lines (CK-B, HS-2, and UC729) and four T cell lines (Molt-4, Jurkat, HUT7 ...
http://www.aegis.org/aidsline/1992/jun/m9260012.html
File Name: m9260012.html, Size: 10KB, Last Modified: Sunday, June 28, 1992 at 8:12:04 PM
Abstract: The results also showed that CD4 cells can recognise and react to another distinct subtype of adenovirus, regardless of which subtype the person was infected with initially. The authors say this means all subtypes of adenovirus are likely to be unsuitable in HIV vaccines. ...
http://www.aegis.org/pubs/aidswkly/2009/aw091111.html
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Abstract: Enterocytozoon bieneusi is a microsporidian that causes a severe, debilitating, chronic diarrhea in some patients with the acquired immunodeficiency syndrome. Specific diagnosis of E. bieneusi currently requires an invasive biopsy procedure and time-consuming preparation of specimens for electron microscopy. Our attem ...
http://www.aegis.org/aidsline/1996/jul/m9670346.html
File Name: m9670346.html, Size: 9KB, Last Modified: Sunday, July 28, 1996 at 8:12:04 PM
Abstract: If numerous bacterial and parasitic agents have been implicated in the etiology of diarrhea among HIV+ patients, the role of pathogenic enteric viruses was less clear. OBJECTIVE: To determine the prevalence of adenovirus (enteric serotypes and others) in stools of HIV seropositive and seronegative subjects. MATERIAL: ...
http://www.aegis.org/aidsline/1992/dec/m92c3731.html
File Name: m92c3731.html, Size: 9KB, Last Modified: Monday, December 28, 1992 at 8:12:04 PM
Abstract: If numerous bacterial and parasitic agents have been implicated in the etiology of diarrhea among HIV+ patients, the role of pathogenic enteric viruses was less clear. <p><b>OBJECTIVE</b>: To determine the prevalence of adenovirus (enteric serotypes and others) in stools of HIV seropositive and seronegative subjects. ...
http://www.aegis.org/conferences/iac/1992/pob3887.html
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Abstract: Epstein-Barr virus (EBV), progressive multifocal leukoencephalopathy (PML), and adenovirus infection in AIDS are reviewed, including the role of EBV in HIV-associated syndromes (non-Hodgkin s B-cell lymphoma, lymphoid interstitial pneumonia, and hairy leukoplakia); laboratory diagnosis of EBV (peripheral blood mononuc ...
http://www.aegis.org/aidsline/1990/oct/m90a0689.html
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Abstract: A common cold virus used in an experimental HIV vaccine may have been an inappropriate vehicle for stimulating immune cells to fight HIV, a new study suggests. In 2007, researchers halted the STEP trial after it appeared that volunteers who received Merck & Co. s vaccine candidate were more likely to later contract ...
http://www.aegis.org/news/ads/2009/ad091988.html
File Name: ad091988.html, Size: 10KB, Last Modified: Thursday, November 19, 2009 at 3:00:00 PM
Abstract: Recombinant adenoviruses were constructed that contained either the HBsAg coding sequence or the HIV envelope protein coding sequence. The recombinant adenoviruses can replicate normally in cultured human cells. Cells infected with the adenovirus-HBV recombinant secreted HBsAg into the tissue culture medium. This HBsA ...
http://www.aegis.org/aidsline/1989/jan/m8910373.html
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Abstract: Adenovirus type 35 (Ad35) is a group B adenovirus that has been isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders. We have studied the interaction of this unique adenovirus with the immune system by analyzing Ad35 early viral proteins in infected HeLa cells. ...
http://www.aegis.org/aidsline/1988/mar/m8830111.html
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Abstract: The heterologous adenovirus prime/poxvirus boost regimen was generally safe and well tolerated. Boosting adenovirus vector-primed subjects with a poxvirus vector elicited recall CMI responses, but this was not more effective than boosting with a homologous vector. ...
http://www.aegis.org/conferences/croi/2005/505.html
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Abstract: Only few T CD8 responses were observed after culture in seven monkeys. After the second immunization, the boost of the T CD8 response was moderated. A weak T CD4 proliferation response was also detected. Neutralizing Abs against adenovirus were detected after the first immunization but they were higher after the second ...
http://www.aegis.org/conferences/iashivpt/2003/508.html
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Abstract: The adenovirus SIV gag vaccine elicited more potent cellular immune responses than other vaccines evaluated and apparently protected more effectively from SHIV challenge. DNA immunization, especially when given with an adjuvant, also elicited cellular immune responses which resulted in better clinical outcomes. The deg ...
http://www.aegis.org/conferences/iashivpt/2001/lb-o13.html
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Abstract: Adenovirus infections have been reported in as many as one-fifth of bone marrow transplant (BMT) recipients and patients with acquired immunodeficiency syndrome (AIDS), and in a lesser, though still prominent, proportion of organ transplant recipients. The relative contributions of primary infections versus reactivati ...
http://www.aegis.org/aidsline/2000/sep/a0090786.html
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Abstract: The E1B-55K and E4orf6 oncoproteins of adenovirus type 5 are involved in the export of viral mRNAs. Previously, it was suggested that a complex composed of E1B-55K and E4orf6 serves as a nucleocytoplasmic transporter for viral mRNAs in which the E4orf6 protein directs both nuclear import and export. We now demonstrate ...
http://www.aegis.org/aidsline/2000/may/a0051581.html
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Abstract: Scientific data of the highest importance and priority concerning regularities of structural and functional organization of proteins of adenoviruses capsids and peculiarities of expression of the virus genome are as follows: New antigen determinants of hexon and adenovirus fiber have been discovered, their different n ...
http://www.aegis.org/aidsline/1999/aug/a9980667.html
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Abstract: Adenovirus is a recognized cause of considerable morbidity in children with liver transplantation. However, the prevalence and clinical significance of adenoviral infections are unknown for adult OLT recipients. Retrospective review of 168 adult OLT recipients who underwent OLT at NEMC from 1/88 to 10/95 showed 11 pat ...
http://www.aegis.org/aidsline/1998/apr/m9841132.html
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Abstract: Human adenovirus type 5 can be used as a vector to elicit immune responses to antigens expressed from heterologous DNA sequences incorporated into the viral genome, for example in mice immunized intraperitoneally. We have used a recombinant adenovirus which expresses the p55gag antigen of simian immunodeficiency virus ...
http://www.aegis.org/aidsline/1997/aug/m9780411.html
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Abstract: To examine the prevalence of stool viruses and their role in the pathogenesis of diarrhea in HIV infection, we evaluated biopsies and repeated stool samples of 256 HIV-infected patients undergoing diagnostic endoscopy because of diarrhea (n = 136) or other symptoms (n = 120) for bacterial, protozoal, and viral enterop ...
http://www.aegis.org/aidsline/1997/jan/m9710950.html
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Abstract: A mixture of adenoviruses 31 and 49 was isolated from the brain of an AIDS patient with encephalitis. Adenovirus hexon protein was detected in neurons by indirect immunofluorescence. By restriction endonuclease analysis both adenovirus 31 and 49 were shown to be new genotypes. This is the first report of the isolation ...
http://www.aegis.org/aidsline/1996/dec/m96c0105.html
File Name: m96c0105.html, Size: 9KB, Last Modified: Saturday, December 28, 1996 at 8:12:04 PM