Your Search for adoptive immune transfer or adoptive immunotherapy matched 125 Documents (Page 1 of 5).
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Abstract: The previously reported increases in CD4 counts, percentage of CD4, and CD4:CD8 ratios now appear durable at a median of 3.3 years after completing adoptive immunotherapy infusions. Disease stability is suggested by the constant rate of HIV-related events. These data support the premise that infusions of ex vivo co-sti ...
http://www.aegis.org/conferences/croi/2006/482.html
File Name: 482.html, Size: 7KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: Tumor growth can increase the number of immature bone marrow-derived CD34+ cells that exhibit natural suppressor (NS) activity toward T-cell function. Using a metastatic Lewis lung carcinoma (LLC-LN7) tumor model, these CD34+ NS cells were shown to be present within the s.c. primary tumor tissue, but their levels decl ...
http://www.aegis.org/aidsline/2000/jul/a0071242.html
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Abstract: Researchers at the Fred Hutchinson Cancer Research Center and the University of Washington are studying a form of adoptive immunotherapy. In this form of adoptive immunotherapy, a patient s HIV-specific cytotoxic T lymphocytes (CTC) are expanded and then are reinfused into the patient in an effort to boost the immune ...
http://www.aegis.org/aidsline/2000/may/a0050657.html
File Name: a0050657.html, Size: 7KB, Last Modified: Sunday, May 28, 2000 at 8:12:04 PM
Abstract: Adoptive immunotherapy strategies using antigen specific cytotoxic T-cells are becoming increasingly prevalent as treatments for HIV. We have explored methods to increase the expansion of HIV-specific CTL from peripheral blood using canarypox based constructs. These constructs were engineered to express and process HI ...
http://www.aegis.org/aidsline/1996/nov/m96b0367.html
File Name: m96b0367.html, Size: 9KB, Last Modified: Thursday, November 28, 1996 at 8:12:04 PM
Abstract: In both CD8 depleted PBMC and DC the expression ranged from 20-80% as determined by flow cytometry methods. Analysis of cytoxicity against targets expressing HIV proteins and HIV repression assays imply antigen specific changes which were not induced by polyclonal activation. Antigen specific activation and expansion o ...
http://www.aegis.org/conferences/croi/1996/441.html
File Name: 441.html, Size: 8KB, Last Modified: Sunday, January 28, 1996 at 8:12:04 PM
Abstract: SEATTLE, Jan. 4 /PRNewswire/ -- Researchers at the Fred Hutchinson Cancer Research Center (FHCRC), the University of Washington (UW) and Targeted Genetics Corp. (Nasdaq: TGEN - news) announced the publication of data from a Phase I study evaluating a new concept in the therapy of HIV-1 infection. The paper, titled In v ...
http://www.aegis.org/news/pr/1999/pr990101.html
File Name: pr990101.html, Size: 14KB, Last Modified: Monday, January 04, 1999 at 3:00:00 PM
Abstract: Reinfusion of HIV-naive immune cells after infection may enable long-term disease control, researchers report. ...
http://www.aegis.org/pubs/aidswkly/2002/aw020305.html
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Abstract: Recombinant T-cell receptors with antibody-like specificity for tumor-associated antigens are successfully used to direct the cytolytic activity of T cells toward tumor cells. Clinical application, however, needs to comply with the low immunogenicity of the recombinant receptor, efficient gene transfer into peripheral ...
http://www.aegis.org/aidsline/2000/dec/a00c0823.html
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Abstract: We generated the DUC18 T cell receptor transgenic mouse expressing an H-2Kd -restricted transgenic T cell receptor specific for the syngeneic CMS5 fibrosarcoma rejection antigen mutated ERK2(136-144). DUC18 mice were capable of specifically eliminating lethal CMS5 tumor challenges, and transfer of DUC18 splenocytes to ...
http://www.aegis.org/aidsline/2000/dec/a00c0922.html
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Abstract: BACKGROUND/AIMS: We investigated the clinical efficacy of systemic and locoregional adoptive immunotherapy (AIT) with or without interleukin-2 ( IL-2 ) against solid metastatic lesions from digestive tract cancer, which are refractory to conventional chemotherapy or radi ...
http://www.aegis.org/aidsline/1999/dec/a99c0966.html
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Abstract: Ag-specific CTL can protect against tumors and some viral infections and may be useful for adoptive immunotherapy. Here, we show that purified CD8+ T cells from naive C57BL/6 mice can be primed in vitro with different immunogenic peptides, which bind to MHC class I gene products, and ...
http://www.aegis.org/aidsline/1999/sep/a9990605.html
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Abstract: We recently reported that immunization with a recombinant MUC-1 vaccinia virus (rVMUC-1) protected C57BL/6 mice from challenge with DF3/MUC-1-positive syngeneic tumors. To elucidate whether anti-MUC-1 tumor immunity, especially MUC-1-specific cytotoxic T lymphocytes (CTI), can be induced in cancer patients by rVMUC-1, ...
http://www.aegis.org/aidsline/1998/dec/m98c6655.html
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Abstract: Adoptive immunotherapy with tumor-infiltrating lymphocytes (TIL) and systemic low dose rIL-2 effectively eradicates pulmonary metastases of the murine MCA-105 sarcoma. We described earlier that host CD8+ T cells are critical for tumor eradication and that successful treatment is associated with production of high leve ...
http://www.aegis.org/aidsline/1998/jul/m9871106.html
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Abstract: HIV-1 infection results in the loss of CD4+ T helper lymphocytes which make up the immune repertoire. This leads to opportunistic infections that define AIDS. Here, we show that CD4 T cell lines from normal donors with specificity for different antigens can be rendered resistant to HIV-1 replication by retroviral tran ...
http://www.aegis.org/aidsline/1998/apr/m9841781.html
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Abstract: We have previously reported that the poorly immunogenic D5 melanoma transduced to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) will elicit immunity in tumor-draining lymph node (TDLN) cells after subcutaneous inoculation. After in vitro activation with anti-CD3 and interleukin-2 ( ...
http://www.aegis.org/aidsline/1997/aug/m9780454.html
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Abstract: Our goal was to identify the mechanism of adoptive cellular immunotherapy. We developed a congenic C57 murine model utilizing a standard methylcholanthrene-induced pulmonary metastases model. Treatment of the host with an anti-CD8 monoclonal antibody rendered therapy with TIL and ...
http://www.aegis.org/aidsline/1997/jul/m9770051.html
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Abstract: PURPOSE: The purpose of this study was to determine whether adoptive transfer of murine cytomegalovirus (MCMV)-immune lymph node cells prevents retinitis in immunosuppressed mice. METHODS: Adult BALB/c mice were thymectomized and T-cell depleted using rat monoclonal antibodies spec ...
http://www.aegis.org/aidsline/1997/may/m9751132.html
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Abstract: Various clinical observations have implicated T cells in the control of chronic myeloid leukemia (CML). These observations have in recent years been supported by laboratory results indicating the presence of CML-specific T cells in the lymphocyte repertoire of both normal healthy individuals and disease-bearing patien ...
http://www.aegis.org/aidsline/1997/apr/m9741385.html
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Abstract: Recognition of tumor-associated antigen in the context of MHC, and subsequent activation of T-lymphocytes, are mediated by the alphabeta heterodimer of the T-cell receptor (TCR). The specificity of a TCR is determined by variable regions of alpha and beta chains (Valpha and Vbeta) and the third complimentary determini ...
http://www.aegis.org/aidsline/1997/mar/m9731541.html
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Abstract: Adoptive transfer of tumor-sensitized T lymphocytes has demonstrated therapeutic efficacy in animal tumor models and in some patients with melanoma and renal cell cancers. In experimental settings, T lymphocytes derived from lymph nodes LNs) draining progressively growing tumors can be activated ex vivo to generate tu ...
http://www.aegis.org/aidsline/1997/jan/m9710857.html
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Abstract: The development of successful adoptive immunotherapy for human virus infections is predicated on an understanding of the effector cells and mechanisms essential for providing the host with a protective response to acute infection and the requirements for long-term in vivo survival of transferred cells that will be nec ...
http://www.aegis.org/aidsline/1995/oct/m95a0310.html
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Abstract: To establish an efficient cell-culture system for adoptive immunotherapy, we attempted to use lipopolysaccharide(LPS)-activated B cells (LPS blasts) as costimulatory-signal-providing cells in the in vitro induction of antitumor effector cells. Both normal and tumor-draining lymph node cells were efficiently activated ...
http://www.aegis.org/aidsline/1995/aug/m9580934.html
File Name: m9580934.html, Size: 10KB, Last Modified: Monday, August 28, 1995 at 8:12:04 PM
Abstract: BACKGROUND. Previously we demonstrated that optimal doses of tumor-infiltrating lymphocytes (TIL) concomitant with recombinant interleukin-2 (rIL-2) effectively mediated complete tumor regression of murine 3-day pulmonary metastases. METHODS. In the present study we have investigated the contribution of the host immun ...
http://www.aegis.org/aidsline/1995/jun/m9560778.html
File Name: m9560778.html, Size: 11KB, Last Modified: Wednesday, June 28, 1995 at 8:12:04 PM
Abstract: In contrast with red cells, platelets, and granulocytes, hemotherapy using lymphocytes and monocytes is only beginning to be explored. Blood banks and transfusion services, the traditional sources of expertise in sterile cell processing, storage, and transfusion, have played an integral role in the early technical dev ...
http://www.aegis.org/aidsline/1995/may/m9550193.html
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Abstract: We performed repeated continuous flow cytaphereses (CFC) on 13 asymptomatic HIV-1-infected patients to study the feasibility of cell separation procedures to recover high yields of peripheral blood T-lymphocytes for adoptive immunotherapy in HIV-infected patients and to determine immunological and virological alterati ...
http://www.aegis.org/aidsline/1995/apr/m9541010.html
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Abstract: The conventional treatments of cancer are surgery, chemotherapy and radiotherapy. However, the therapeutic efficacy of these treatments are still far from satisfactory in most cases. With the development of immunology and increasing understanding in tumor immunology, immunotherapy has moved onto the stage of cancer tr ...
http://www.aegis.org/aidsline/1994/dec/m94c4342.html
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Abstract: Anti-HIV genetic treatment of antigen-specific human CD4 lymphocytes for adoptive immunotherapy of opportunistic infections in AIDS.Gene Ther. 1997 Nov;4(11)1216-24. Unique Identifier : AIDSLINE MED/98086582 Manca F; Fenoglio D; Franchin E; Saverino D; Li Pira G; Buffa F; Bignardi D; Del Pup L; Palu G; Dep ...
http://www.aegis.org/aidsline/1994/apr/m9841781.html
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Abstract: NIAID Mobilizes Teams of Scientists to Advance Novel AIDS Therapies. National Institute of Allergy and Infectious Diseases (NIAID) EMBARGOED FOR RELEASE, Thursday, Sept. 1, 1994 - 5 p.m. Eastern Time Mary Jane Walker - (301) 402-1663The National Institute of Allergy and Infectious Diseases (. has launched a new progra ...
http://www.aegis.org/pubs/cdc_fact_sheets/1994/cdc94038.html
File Name: cdc94038.html, Size: 9KB, Last Modified: Saturday, October 01, 1994 at 11:00:00 PM
Abstract: ...
http://www.aegis.org/aidsline/1989/sep/m8990072.html
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Abstract: Patients with acquired immunodeficiency syndrome (AIDS)-related complex and asymptomatic individuals seropositive for human immunodeficiency virus (HIV) have depressed natural killer (NK) activity. Normal human macrophages cultured for 3-7 days significantly up-regulated the NK activity of mononuclear cells obtained f ...
http://www.aegis.org/aidsline/1989/jul/m8970498.html
File Name: m8970498.html, Size: 9KB, Last Modified: Wednesday, January 07, 2009 at 5:26:01 AM