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1. AEGiS-Glasgow [P311] Search of occult hepatitis B in a cohort of HIV-infected patients (100%)
Abstract: Our study shows that HIV pts rarely hide HBV occult infection. HIV pts present a previous HBV infection and a lack of immune function that could be facilitating factors for this infection. Probably an ARV therapy based on drugs which are active on HIV and HBV could inhibit HBV replication. Although much more research i ...
http://www.aegis.org/conferences/hiv-glasgow/2006/p311.html
File Name: p311.html, Size: 6KB, Last Modified: Sunday, November 12, 2006 at 8:12:04 PM

2. AEGiS-Glasgow [P317] Limited value of alanine aminotransferase levels in the management of chronic hepatitis C in HIV-infected patients (100%)
Abstract: ALT levels are not useful in the management of chronic hepatitis C in HIV infected patients: up to 17% of patients with no liver disease have abnormal levels, and up to 41% of patients with normal levels have severe liver damage. ...
http://www.aegis.org/conferences/hiv-glasgow/2006/p317.html
File Name: p317.html, Size: 6KB, Last Modified: Sunday, November 12, 2006 at 8:12:04 PM

3. hcv news (100%)
Abstract: SAVE ADAP Alert ...
http://www.aegis.org/factshts/network/altcirrhosis.html
File Name: altcirrhosis.html, Size: 5KB, Last Modified: Friday, January 27, 2006 at 6:23:43 AM

4. Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian Hepatitis Lamivudine Trial Group. (100%)
Abstract: In the reported Asian lamivudine trial, the rate of hepatitis B e antigen (HBeAg) seroconversion, defined as HBeAg/hepatitis B virus (HBV) DNA seroclearance and development of anti-HBe, during 52 weeks of treatment was only 13% to 16%. To evaluate whether any factors influenced HBeAg seroconversion, data from 345 pati ...
http://www.aegis.org/aidsline/1999/nov/a99b0398.html
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5. Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors. (100%)
Abstract: BACKGROUND AND AIM: Serum alanine aminotransferase (ALT) level is the most common screening test as part of a routine evaluation of liver damage. In order to determine the factors influencing this liver function test in normal subjects, the relationship between ALT level and gender, age and body mass index (BMI) was s ...
http://www.aegis.org/aidsline/1999/aug/a9980475.html
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6. Clinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels. (100%)
Abstract: This study was aimed to evaluate demographic, clinical, histological, and virological characteristics of 46 hepatitis C virus (HCV) carriers with persistently normal alanine transaminase (ALT) levels and to compare the results with those obtained in a group of 52 HCV-RNA-positive patients with elevated ALT levels. Sub ...
http://www.aegis.org/aidsline/1998/mar/m9830998.html
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7. Virological analysis of HIV-1-infected long term asymptomatic subjects. (96%)
Abstract: Long-term asymptomatic (ALT) status was defined as HIV infection for at least 8 years with stability of CD4 cell counts (greater than or equal to 600/mm(3)) and no antiretroviral therapy. As yet, fifty-eight patients have been enrolled in the study. At the time of the first virological evaluation following enrollment, ...
http://www.aegis.org/aidsline/1997/jul/m9770817.html
File Name: m9770817.html, Size: 9KB, Last Modified: Monday, July 28, 1997 at 8:12:04 PM

8. AEGiS-04CROI: Virological analysis of HIV-1-infected long term asymptomatic subjects. (96%)
Abstract: Long-term asymptomatic (ALT) status was defined as HIV infection for at least 8 years with stability of CD4 cell counts (greater than or equal to 600/mm<sup><font size= ...
http://www.aegis.org/conferences/croi/1997/473.html
File Name: 473.html, Size: 6KB, Last Modified: Wednesday, January 22, 1997 at 8:12:04 PM

9. AEGiS-15IAC: Six months follow up of Highly Active Antiretroviral Therapy (HAART) initiated during pregnancy in Thailand. (89%)
Abstract: BACKGROUND: In the context of a perinatal HIV Prevention trial in Thailand , severely immunocompromized women were offered HAART during pregnancy instead of enrolling in the study. METHODS: Immunocompromised Pregnant women who opted for HAART initiation received baseline clinical and biological evaluations and were fol ...
http://www.aegis.org/conferences/iac/2004/thpeb7088.html
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10. Chronic hepatitis C infection in patients with end stage renal disease: characterization of liver histology and viral load in patients awaiting renal transplantation. (88%)
Abstract: OBJECTIVES: Hepatitis C virus (HCV) is common in patients with end stage renal disease (ESRD) awaiting renal transplantation (RT). However, few data are available on the liver histology and viral titer in these patients relative to patients with HCV and normal renal function. The aims of this study were to assess live ...
http://www.aegis.org/aidsline/2000/mar/a0030589.html
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11. AEGiS-Glasgow [P235] Active chronic HCV infection with normal transaminases more common among HIV-infected females (80%)
Abstract: Around one fifth of the HIV-infected pts with HCV replication analyzed had normal transaminases. Females had more often normal transaminases compared to males. Therefore, HIV-infected pts with positive anti-HCV antibody need a complete evaluation including plasma HCV RNA levels even when transaminases are within normal ...
http://www.aegis.org/conferences/hiv-glasgow/2004/p235.html
File Name: p235.html, Size: 6KB, Last Modified: Sunday, November 14, 2004 at 8:12:04 PM

12. AEGiS-15IAC: Exposure to Lopinavir/r is a risk factor for grade 3/4 elevation of ALT in HIV and hepatitis B (HBV) and/or C (HCV)co-infected patients. (80%)
Abstract: BACKGROUND: To assess the risk of hepatotoxicity in patients co-infected with HIV and HBV and/or HCV initiating newer ARV agents. METHODS: A retrospective chart review was done on HIV patients co-infected with hepatitis from 2 Toronto centres. GEE logistic regression assessed the association between specific clinical a ...
http://www.aegis.org/conferences/iac/2004/mopeb3281.html
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13. [WePE0087] CAN ROUTINE ALANINE TRANSAMINASE (ALT) MONITORING BE SIMPLIFIED IN PATIENTS STARTING A NEVIRAPINE CONTAINING ANTIRETROVIRAL TREATMENT REGIMEN? AN EXPERIENCE FROM A CLINIC SETTING IN MAPUTO, MOZAMBIQUE (72%)
Abstract: It is justified to perform routine ALT measurements at baseline and 0.5M in specific risk-groups such as pregnant women, patients on hepatotoxic medication or those symptomatic for liver dysfunction. In all other patients, it would be acceptable to drop systematic ALT measurements at baseline and at M0.5. ...
http://www.aegis.org/conferences/iac/2006/wepe0087.html
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14. [126] HEPATOTOXICITY OF RITONAVIR-BOOSTED INDINAVIR (IDV/R 800/100 MG TWICE DAILY) AND SAQUINAVIR (SAQ/R 1000/100 MG TWICE DAILY) IN A PHASE IV, RANDOMIZED, OPEN-LABEL, AND MULTICENTRE TRIAL IN ADULT HIV-1 INFECTION: THE MaxCmin1 TRIAL (72%)
Abstract: The reported hepatitis prevalence was relatively low. Bilirubin elevation was seen in the IDV/r arm. No clinically significant excess hepatotoxicity was seen in hepatitis patients compared to the overall study population during r-tx. ...
http://www.aegis.org/conferences/lipo/2003/126.html
File Name: 126.html, Size: 7KB, Last Modified: Wednesday, July 09, 2003 at 6:29:23 AM

15. AEGiS-Glasgow [P161] ASSESSMENT OF HEPATIC CYTOLYSIS IN PATIENTS SWITCHED FROM A PROTEASE INHIBITOR (PI)-CONTAINING REGIMEN TO A NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR (NNRTI)-CONTAINING REGIMEN (72%)
Abstract: Incidence of transaminases elevation > 5N after PI–NNRTI switch was 10% (4/41) during the first year of follow-up. Intercurrent acute or chronic viral hepatitis was present in 3/4 patients. Moderate transaminases elevation was present at the time of PI–NNRTI switch in 22% of patients, 80% of whom having a co-infection ...
http://www.aegis.org/conferences/hiv-glasgow/2000/p161.html
File Name: p161.html, Size: 7KB, Last Modified: Sunday, October 22, 2000 at 8:12:04 PM

16. A Prospective, Community-Based Evaluation of Liver Enzymes in Individuals With Hepatitis C After Drug Use (72%)
Abstract: Researchers measured serum alanine transaminase (ALT) levels, which are often used to select for treatment and liver biopsy in patients with hepatitis C virus, to test whether ALT levels vary over time in HCV-infected patients. They prospectively measured ALT levels for 25 months in 1,235 patients with a history of dru ...
http://www.aegis.org/news/ads/1999/ad990561.html
File Name: ad990561.html, Size: 10KB, Last Modified: Friday, April 09, 1999 at 3:00:00 PM

17. AEGiS-08IAC: Chronic viral hepatitis in homosexual men with or without HIV infection. (72%)
Abstract: <p><b>OBJECTIVE</b>: To assess the prevalence and the course of liver disease due to HBV, HDV and HCV chronic hepatitis (CH) in male homosexuals (OMO) with or without HIV infection.</p> <p><b>METHODS</b>: Research of HBV and HDV markers by RIA (Abbott), HCVab by ELISA (Abbott, second generation), HIVab by ELISA and ...
http://www.aegis.org/conferences/iac/1992/pob3466.html
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18. [TuPe1.1C42] Liver biopsy (LB) findings in HIV infected patients (HIV+P) with chronic C Hepatitis (CHC) and persistently normal Alanine Transaminase (PNALT) (70%)
Abstract: In HIV infected patients (HIV+P) with chronic Hepatitis C (CHC), persistently normal alanine transaminase (PNALT) correlates with lower fibrosis scores than elevated ALT (EALT). The association found between HCV genotype, duration of HAART and PNALT in this population group merits further study. Although we did not fou ...
http://www.aegis.org/conferences/iashivpt/2005/tupe1-1c42.html
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19. AEGiS-15IAC: Haematogical and Biochemical Response to treatment of HIV-1 infection with a combination of Nevirapine + Stavudine+ lamivudine in Lagos Nigeria. (70%)
Abstract: BACKGROUND: To evaluate the effect of a combination of Nevirapine +Stavidine + Lamivudine on Heamatogical and Biochemical values of HIV-1 positive patients in Lagos. Methods and materials: Fifty patients who met the enrollment criteria for accelera ...
http://www.aegis.org/conferences/iac/2004/b10064.html
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20. AEGiS-15IAC: Prevalence of Hepatitis B Virus or Hepatitis C Virus Co-infection with Human Immunodeficiency Virus in Thai Patients: A Tertiary-care-based Study. (70%)
Abstract: BACKGROUND: Hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV share the route of transmission. HBV or HCV co-infection with HIV has been associated with a reduced survival rate, increase the risk of progression to severe liver disease, and increase the risk of hepatotoxicity associated with active antiretrovira ...
http://www.aegis.org/conferences/iac/2004/tupec4682.html
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21. Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B. (70%)
Abstract: We evaluated the safety and efficacy of long-term lamivudine monotherapy in a group of 25 patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B. Lamivudine was administered in a daily dose of 150 mg for a mean of 26 +/- 7 months and ...
http://www.aegis.org/aidsline/2000/dec/a00c0202.html
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22. Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea. (70%)
Abstract: It has been suggested that hepatitis B e antigen (HBeAg) seroconversion after lamivudine therapy is durable in Caucasians with chronic hepatitis B (CHB). However, little is known whether it is also durable in endemic areas of hepatitis B virus (HBV) infection. We evaluated the posttreatment durability of lamivudine-in ...
http://www.aegis.org/aidsline/2000/dec/a00c0204.html
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23. Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B [see comments] (70%)
Abstract: Asian lamivudine trial has shown that hepatitis B e antigen (HBeAg) seroconversion rate during 1 year of lamivudine therapy was only 16% but was 64% in the subgroup of patients with a pretherapy serum alanine transaminase (ALT) level over 5 times the upper limit of normal (ULN). To test whether ALT rebound following c ...
http://www.aegis.org/aidsline/2000/nov/a00b0577.html
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24. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group [see comments] (70%)
Abstract: BACKGROUND & AIMS: One-year lamivudine therapy significantly suppressed hepatitis B virus (HBV) replication, improved hepatic necroinflammatory activity, and prevented progression of fibrosis. However, the effects of prolonged therapy are unknown. METHODS: A total of 334 Asian patients with chronic hepatitis B from ...
http://www.aegis.org/aidsline/2000/oct/a00a1014.html
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25. Serum alanine transaminase level is a good predictor of response to interferon alfa therapy for chronic hepatitis B in human immunodeficiency virus-infected patients [letter] (70%)
Abstract: ...
http://www.aegis.org/aidsline/2000/jun/a0061162.html
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26. Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15,250 pregnant women. (70%)
Abstract: The prevalence and natural course of chronic hepatitis C virus (HCV) infection was evaluated in 15,250 consecutive pregnant women. The rate of HCV vertical and perinatal transmission was also assessed. The presence of anti-HCV was tested by means of EIA III and confirmed by recombinant immunoblot assay III. Alanine tr ...
http://www.aegis.org/aidsline/2000/may/a0051651.html
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27. Extended lamivudine retreatment for chronic hepatitis B: maintenance of viral suppression after discontinuation of therapy. (70%)
Abstract: In patients with chronic hepatitis B, brief lamivudine therapy suppresses hepatitis B virus (HBV) DNA but results infrequently in sustained losses of virus replication posttreatment. We evaluated treatment response and its posttreatment durability during up to 18 months of lamivudine therapy (100 mg/d) in 24 patients ...
http://www.aegis.org/aidsline/1999/dec/a99c0216.html
File Name: a99c0216.html, Size: 9KB, Last Modified: Tuesday, December 28, 1999 at 8:12:04 PM

28. Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy [see comments] (70%)
Abstract: Lamivudine is a potent inhibitor of hepatitis B virus (HBV) replication, but its long-term use may be associated with HBV tyrosine-methionine-aspartate-aspartate (YMDD) motif mutation. To examine the clinical features and course after emergence of YMD ...
http://www.aegis.org/aidsline/1999/oct/a99a0607.html
File Name: a99a0607.html, Size: 10KB, Last Modified: Thursday, October 28, 1999 at 8:12:04 PM

29. Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men. (70%)
Abstract: The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. In a series of 132 (65 anti-HIV positive) homosexual non-drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) re ...
http://www.aegis.org/aidsline/1999/jul/a9970451.html
File Name: a9970451.html, Size: 9KB, Last Modified: Wednesday, July 28, 1999 at 8:12:04 PM

30. Viral load and clinicopathological features of chronic hepatitis C (1b) in a homogeneous patient population. (70%)
Abstract: Monitoring the progression of hepatitis C virus (HCV) includes clinical, biochemical, and histological parameters. Quantitation of viral load by reverse-transcription polymerase chain reaction (RT-PCR) may offer a more reliable marker of disease status. Conflicting reports on viral titers may reflect heterogeneity of ...
http://www.aegis.org/aidsline/1999/jun/a9960930.html
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