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1.	Specificity in the binding of aminoglycosides to HIV-RRE RNA. (100%) Abstract: Quantitative studies of the binding of neomycin B to RRE constructs are carried out to determine the relationship between non-Watson Crick base-paired elements in the RNA and aminoglycoside binding. The RRE region contains two unpaired domains containing a single base bulge and a bubble structure, respectively. Deleti ... http://www.aegis.org/aidsline/1999/sep/a9990481.html File Name: a9990481.html, Size: 10KB, Last Modified: Tuesday, September 28, 1999 at 8:12:04 PM
2.	Specificity of aminoglycoside binding to RNA constructs derived from the 16S rRNA decoding region and the HIV-RRE activator region. (100%) Abstract: Aminoglycoside antibiotics can bind to many different types of RNA molecules. It was of interest to determine the nature of the selectivity of binding of aminoglycosides to important, biologically relevant RNA targets. Fluorescence anisotropy methods were developed to quantitatively measure aminoglycoside affinities t ... http://www.aegis.org/aidsline/1997/may/m9751261.html File Name: m9751261.html, Size: 10KB, Last Modified: Wednesday, May 28, 1997 at 8:12:04 PM
3.	The effect of heat upon the interaction between aminoglycosides and semi-synthetic penicillins in human serum: a consideration for HIV infectious serum. (64%) Abstract: We conducted 2 experiments to study the effect of heat on the interaction between aminoglycosides and semi-synthetic penicillins in human serum. In one experiment, human serum spiked with either gentamicin or tobramycin at a concentration of 4.7 mg/l plus carbenicillin, ticarcillin, piperacillin, mezlocillin, or azloc ... http://www.aegis.org/aidsline/1987/nov/m87b0259.html File Name: m87b0259.html, Size: 9KB, Last Modified: Wednesday, January 07, 2009 at 5:05:40 AM
4.	Observations on the possible origin of Mycoplasma fermentans incognitus strain based on antibiotic sensitivity tests. (64%) Abstract: Mycoplasma fermentans (incognitus strain), isolated during transfection studies in NIH/3T3 cells with DNA extracted from Kaposi s sarcoma tissue from a patient suffering from AIDS, showed high levels of resistance to numerous aminoglycoside antibiotics (MICs > 250 to > 500 mg/L) and in this respect matched the aminogl ... http://www.aegis.org/aidsline/1997/jul/m9771442.html File Name: m9771442.html, Size: 9KB, Last Modified: Monday, July 28, 1997 at 8:12:04 PM
5.	AEGiS-13IAC: Anti-HIV activity of novel aminoglycoside-arginine conjugates at early stages of infection. (51%) Abstract: <p><b>BACKGROUND:</b> Conjugates of L-arginine with aminoglycosides have already been described as potent in vitro inhibitors of HIV-1 Tat-transactivation responsive element interaction. The polycationic nature of these agents lead us to suggests that they may be active against HIV-1 replication by inhibiting earlier ... http://www.aegis.org/conferences/iac/2000/mopea2014.html File Name: mopea2014.html, Size: 8KB, Last Modified: Sunday, July 09, 2000 at 8:12:04 PM
6.	Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection. (38%) Abstract: Conjugates of L-arginine with aminoglycosides have already been described as potent in vitro inhibitors of the HIV-1 Tat-trans-activation responsive element interaction. The polycationic nature of these agents leads us to suggest that they may be active against HIV-1 replication by inhibiting earlier stages of the vir ... http://www.aegis.org/aidsline/2000/oct/a00a0617.html File Name: a00a0617.html, Size: 10KB, Last Modified: Saturday, October 28, 2000 at 8:12:04 PM
7.	Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy. (38%) Abstract: Rev is an essential HIV-1 regulatory protein that binds the Rev responsive element (RRE) within the env gene of the HIV-1 RNA genome and is involved in transport of unspliced or partially spliced viral mRNA from the cell nucleus to the cytoplasm. Previous studies have shown that a short alpha-helical peptide derived f ... http://www.aegis.org/aidsline/2000/sep/a0091514.html File Name: a0091514.html, Size: 11KB, Last Modified: Thursday, September 28, 2000 at 8:12:04 PM
8.	Neomycin B inhibits splicing of the td intron indirectly by interfering with translation and enhances missplicing in vivo. (38%) Abstract: The aminoglycoside antibiotic neomycin B inhibits translation in prokaryotes and interferes with RNA-protein interactions in HIV both in vivo and in vitro. Hitherto, inhibition of ribozyme catalysis has only been observed in vitro. We therefore monitored the activity of neomycin B and several other aminoglycoside anti ... http://www.aegis.org/aidsline/1999/mar/a9931101.html File Name: a9931101.html, Size: 10KB, Last Modified: Sunday, March 28, 1999 at 8:12:04 PM
9.	Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism. (38%) Abstract: Neomycin inhibits the binding of Tat-derived peptides to the trans-activating region (TAR) of HIV-1 RNA. Kinetic studies reveal that neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. Neomycin effects a co ... http://www.aegis.org/aidsline/1998/jul/m9870929.html File Name: m9870929.html, Size: 9KB, Last Modified: Wednesday, July 29, 1998 at 6:29:23 AM
10.	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle. (38%) Abstract: A series of 10 indolocarbazole derivatives, analogues to the antitumor antibiotic rebeccamycin, bearing modifications at the imide heterocycle were synthesized. They bear an N-methyl imide, N-methyl amide, or anhydride function instead of the original imide. Their inhibitory potencies toward topoisomerase I were exami ... http://www.aegis.org/aidsline/1998/jul/m9870276.html File Name: m9870276.html, Size: 10KB, Last Modified: Wednesday, July 29, 1998 at 6:29:23 AM
11.	[Aminoglycoside treatment I. Administration of gentamicin once versus three times daily] gange daglig. (38%) Abstract: Gentamicin is the most commonly used aminoglycoside in Danish hospitals. ... http://www.aegis.org/pubs/medline/1998/jan/m9810281.html File Name: m9810281.html, Size: 5KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
12.	Design, synthesis and biological activity of aminoglycoside-like inhibitors of the Rev/RRE interaction. (38%) Abstract: Objective: To identify inhibitors of HIV which function by disrupting the Rev/RRE(Rev responsive element) interaction, which were designed by using a proprietary molecular modelling docking program. Methods: Illustration of the use of a proprietary molecular modelling docking program of the RBE(Rev binding element) to ... http://www.aegis.org/aidsline/1997/jan/m9716081.html File Name: m9716081.html, Size: 8KB, Last Modified: Tuesday, January 28, 1997 at 8:12:04 PM
13.	AEGiS-11IAC: Design, synthesis and biological activity of aminoglycoside-like inhibitors of the Rev/RRE interaction. (38%) Abstract: To identify inhibitors of HIV which function by disrupting the Rev/RRE(Rev responsive element) interaction, which were designed by using a proprietary molecular modelling docking program. <p><b>METHODS</b>: Illustration of the use of a proprietary molecular modelling docking program of the RBE(Rev binding element) to ... http://www.aegis.org/conferences/iac/1996/moa1052.html File Name: moa1052.html, Size: 5KB, Last Modified: Sunday, July 07, 1996 at 8:12:04 PM
14.	Optimal adaptive control of pharmacodynamic effects with aminoglycoside antibiotics: a required approach for the future. (38%) Abstract: Many factors are considered in designing optimal drug regimens, including dose, route of administration, and the frequency and rate of administration. It is evident that the first parameter to be considered in dosage regimen determinations is the pharmacokinetics of the drug in the treated patient, or more extensively ... http://www.aegis.org/aidsline/1995/jan/m9510588.html File Name: m9510588.html, Size: 10KB, Last Modified: Saturday, January 28, 1995 at 8:12:04 PM
15.	Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity. (38%) Abstract: The bacterial neomycin phosphotransferase gene driven by the Moloney mouse leukemia virus long terminal repeat (LTR) or SV40 early region promoter was introduced into the human promonocyte-macrophage cell line, U937, and into the pluripotential human embryonic teratocarcinoma cell line, NT2/D1. Clonally derived cell l ... http://www.aegis.org/aidsline/1992/mar/m9230189.html File Name: m9230189.html, Size: 11KB, Last Modified: Saturday, March 28, 1992 at 8:12:04 PM
16.	Docking of cationic antibiotics to negatively charged pockets in RNA folds. (32%) Abstract: The binding of aminoglycosides to RNA provides a paradigm system for the analysis of RNA-drug interactions. The electrostatic field around three-dimensional RNA folds creates localized and defined negatively charged regions which are potential docking sites for the cationic ammonium groups of aminoglycosides. To explo ... http://www.aegis.org/aidsline/1999/jul/a9970379.html File Name: a9970379.html, Size: 10KB, Last Modified: Wednesday, July 28, 1999 at 8:12:04 PM
17.	[70] MULTI-TARGETING HIV-1 ENTRY BY AMINOGLYCOSIDE-ARGININE CONJUGATES (AACS) AND THE MECHANISMS OF HIV-1 AACS RESISTANCE (25%) Abstract: The role of the V3 domain in the interaction of gp120 with CXCR4 has not been directly demonstrated; variable domains such as V1/V2 and V3 of gp120 can both contribute to the interaction with CXCR4 coreceptor. Therefore, mutations in NeoR6 resistant isolates may confer resistance by allowing the interaction of gp120 wi ... http://www.aegis.org/conferences/hivdrw/2005/70.html File Name: 70.html, Size: 6KB, Last Modified: Wednesday, June 08, 2005 at 6:29:23 AM
18.	Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B. (25%) Abstract: Binding of human immunodeficiency virus type 1 (HIV-1) transactivator (Tat) protein to Tat-responsive RNA (TAR) is essential for viral replication and is considered a promising starting point for the design of anti-HIV drugs. NMR spectroscopy indicated that the aminoglycosides neomycin B and ribostamycin bind to TAR a ... http://www.aegis.org/aidsline/2000/oct/a00a0470.html File Name: a00a0470.html, Size: 10KB, Last Modified: Saturday, October 28, 2000 at 8:12:04 PM
19.	Aminoglycoside-arginine conjugates that bind TAR RNA: synthesis, characterization, and antiviral activity. (25%) Abstract: Regulation of HIV gene expression is crucially dependent on binding of the trans-activator protein, Tat, to the trans-activation response RNA element, TAR, found at the 5 end of all HIV-1 transcripts. Tat-TAR interaction is mediated by a short arginine-rich domain of the protein. Disruption of this interaction could, ... http://www.aegis.org/aidsline/2000/jun/a0061235.html File Name: a0061235.html, Size: 11KB, Last Modified: Wednesday, June 28, 2000 at 8:12:04 PM
20.	In vitro activity of Arbekacin against Mycobacterium avium complex alone and with Clarithromycin and Ethambutol in different combinations. (25%) Abstract: The optimal management of disseminated MAC infection in AIDS patients remains unresolved. The search of new treatment modalities has become a challenge. There are no reports of the effectiveness of ABK, a broad-spectrum aminoglycoside, against MAC. Materials and Methods: The MIC of ABK and the activity of different an ... http://www.aegis.org/aidsline/2000/may/a0050511.html File Name: a0050511.html, Size: 10KB, Last Modified: Sunday, May 28, 2000 at 8:12:04 PM
21.	Modulation of RNA function by aminoglycoside antibiotics. (25%) Abstract: One of the most important families of antibiotics are the aminoglycosides, including drugs such as neomycin B, paromomycin, gentamicin and streptomycin. With the discovery of the catalytic potential of RNA, these antibiotics became very popular due to their RNA-binding capacity. They serve for the analysis of RNA func ... http://www.aegis.org/aidsline/2000/apr/a0040138.html File Name: a0040138.html, Size: 9KB, Last Modified: Friday, April 28, 2000 at 8:12:04 PM
22.	Approaches to therapy against Cryptosporidium. (25%) Abstract: Cryptosporidium parvum, an enteric protozoa, causes chronic diarrhea and wasting in AIDS against which there is not consistently effective treatment. The currently used chemotherapeutic agents are only partially effective under laboratory conditions and in clinical trials. Newly developed and tested compounds do not l ... http://www.aegis.org/aidsline/1998/aug/m9880116.html File Name: m9880116.html, Size: 9KB, Last Modified: Saturday, August 29, 1998 at 6:29:23 AM
23.	[Aminoglycoside treatment II: Dosage regimes at the departments of internal medicine in Denmark] afdelinger i Danmark. (25%) Abstract: The aim of this study was to get a general view of the habitual practice of the usage of aminoglycosides in Danish medical depa ... http://www.aegis.org/pubs/medline/1998/jan/m9810280.html File Name: m9810280.html, Size: 5KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
24.	[Enterococcal resistance to beta-lactam and aminoglycoside antibiotics] aminoglucosidos. (25%) Abstract: ... http://www.aegis.org/pubs/medline/1998/jan/m9815831.html File Name: m9815831.html, Size: 4KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
25.	[Febrile neutropenia: empiric antibiotic therapy from 1975 to 1997] (25%) Abstract: Monotherapy with ceftazidime, cefepime, imipenem or meropenem for the empiric treatment of febrile neutropenia appears as effec ... http://www.aegis.org/pubs/medline/1998/jan/m9815814.html File Name: m9815814.html, Size: 5KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
26.	Multiply antibiotic-resistant gram-negative bacilli in a long-term-care facility: a case-control study of patient risk factors and prior antibiotic use [see comments] (25%) Abstract: OBJECTIVE: To determine the relation between prior exposure to specific antimicrobials and acquisition of gram-negative bacilli ... http://www.aegis.org/pubs/medline/1998/jan/m9814842.html File Name: m9814842.html, Size: 7KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
27.	Telomerase inhibition by RNA-directed antibiotics (Meeting abstract). (25%) Abstract: We report the inhibition of telomerase, a reverse transcriptase which repairs the gaps at the ends of chromosomes, by aminoglycoside antibiotics targeted to the RNA component of this ribonucleoprotein. The best inhibitor was found to be neomycin B, with an IC50 of about 10 uM. Interestingly, paromomycin, an analog in ... http://www.aegis.org/aidsline/1997/jun/m9760106.html File Name: m9760106.html, Size: 8KB, Last Modified: Saturday, June 28, 1997 at 8:12:04 PM
28.	Tetany in a child with AIDS receiving intravenous tobramycin. (25%) Abstract: Aminoglycosides have been reported to cause tetany by inducing renal wasting of magnesium and secondary hypocalcemia. A 9-year-old girl with AIDS was brought to the emergency department because of tetany. She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobra ... http://www.aegis.org/aidsline/1997/feb/m9720272.html File Name: m9720272.html, Size: 9KB, Last Modified: Friday, February 28, 1997 at 8:12:04 PM
29.	Serum paromomycin levels in AIDS patients treated for cryptosporidiosis. (25%) Abstract: Objective: High dose of paromomycin has been proposed for the treatment of cryptosporidiosis in patients with AIDS. This aminoglycoside antibiotic is poorly absorbed after oral administration. However, in order to ensure the lack of systemic toxicity, only limited data are available concerning the serum levels of paro ... http://www.aegis.org/aidsline/1997/jan/m9714879.html File Name: m9714879.html, Size: 9KB, Last Modified: Tuesday, January 28, 1997 at 8:12:04 PM
30.	[The role of aminoglycosides in HIV-infected patients] (25%) Abstract: The frequency of serious infections due to Pseudomonas aeruginosa is increasing among patients with advanced HIV infection; most of the cases are community-acquired. Early diagnosis and adequate treatment--usually with the combination of an anti-pseudomonas beta-lactam antibiotic and an aminoglycoside--have a crucial ... http://www.aegis.org/aidsline/1996/oct/m96a0776.html File Name: m96a0776.html, Size: 8KB, Last Modified: Monday, October 28, 1996 at 8:12:04 PM
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