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Abstract: A retrospective analysis of 99 hepatitis B-positive homosexual men with known human immunodeficiency virus (HIV) status was conducted to study the interaction of concurrent HIV infection on the course of their chronic hepatitis B virus (HBV) infection. All 99 subjects had chronic hepatitis B, 43 of whom were HIV antib ...
http://www.aegis.org/aidsline/1997/feb/m9720771.html
File Name: m9720771.html, Size: 10KB, Last Modified: Friday, February 28, 1997 at 8:12:04 PM
Abstract: OBJECTIVES: Serum aminotransferase levels characteristically fluctuate in chronic hepatitis C, but their relationship to grade (i.e., inflammatory activity) and stage (i.e., degree of fibrosis) of liver disease is uncertain. We therefore correlated aminotransferase levels and liver biopsy findings in 90 patients with ...
http://www.aegis.org/aidsline/1995/nov/m95b0288.html
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Abstract: In about 30% to 40% of patients with chronic hepatitis C, treatment with recombinant interferon alfa (r-IFN alpha) causes a decrease of serum aminotransferases and hepatitis C virus (HCV) RNA. The antiviral mechanism of interferon alfa (IFN alpha) in vivo is unknown. From serial measurements of serum HCV-RNA concentra ...
http://www.aegis.org/aidsline/1996/jun/m9660752.html
File Name: m9660752.html, Size: 10KB, Last Modified: Friday, June 28, 1996 at 8:12:04 PM
Abstract: We determined the enzyme activities of glucose-6-phosphate isomerase, alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase in serum from 23 normal controls, 27 anti-HIV seropositive individuals confirmed by Western blot, and 53 patients with acquired immunodeficiency syndrome (AIDS). There i ...
http://www.aegis.org/aidsline/1989/mar/m8930384.html
File Name: m8930384.html, Size: 8KB, Last Modified: Wednesday, January 07, 2009 at 5:27:33 AM
Abstract: In patients receiving chronic NA therapy, mitochondrial toxicity may manifest as non-specific symptoms with modest levels of hyperlactatemia. Notable metabolic changes in lipid metabolism may occur abruptly increasing triglyceride levels resulting in fatty infiltration of the liver with moderate increases in aminotrans ...
http://www.aegis.org/conferences/iashivpt/2001/523.html
File Name: 523.html, Size: 8KB, Last Modified: Monday, July 09, 2001 at 6:29:23 AM
Abstract: Asymptomatic elevations of liver function tests (LFTs) have been reported in a large percentage of HIV-infected adults but less is known about the pediatric HIV population. We reviewed the records of 125 children who had received ...
http://www.aegis.org/aidsline/1997/aug/m9780285.html
File Name: m9780285.html, Size: 10KB, Last Modified: Thursday, August 28, 1997 at 8:12:04 PM
Abstract: OBJECTIVE: To report a case of fluconazole worsening of liver dysfunction. CASE SUMMARY: A patient with hepatitis experienced worsening of her liver function when treated with fluconazole for a Candida infection in her urine. Elevations in aspartate aminotransferase, alanine aminotransferase, and total bilirubin conce ...
http://www.aegis.org/aidsline/1995/may/m9550761.html
File Name: m9550761.html, Size: 9KB, Last Modified: Sunday, May 28, 1995 at 8:12:04 PM
Abstract: An antisense phosphorothioate oligodeoxynucleotide 27-mer complementary to the rev gene mRNA of the human immunodeficiency virus (HIV-1) was administered to rats through intravenous injections and subcutaneous infusions in order to investigate the disposition of this compound. In addition, nonlethal toxic responses of ...
http://www.aegis.org/aidsline/1994/nov/m94b0293.html
File Name: m94b0293.html, Size: 10KB, Last Modified: Monday, November 28, 1994 at 8:12:04 PM
Abstract: BACKGROUND: An association between use of zidovudine and didanosine and a rare but life-threatening syndrome of hepatic steatosis, lactic acidosis, and myopathy has been reported. OBJECTIVE: To describe the syndrome of hepatic steatosis, lactic acidosis, and myopathy in four patients taking ...
http://www.aegis.org/aidsline/2000/oct/a00a0852.html
File Name: a00a0852.html, Size: 9KB, Last Modified: Saturday, October 28, 2000 at 8:12:04 PM
Abstract: To evaluate the impact of new antiretroviral combinations (HAART: Highly Active Anti Retroviral Therapy) on HCV replication and liver enzyme levels, we analysed the changes in HCV viremia and aminotransferase levels in HIV and HCV co-infected patients. Moreover, to evaluate the influence of HCV infection on the effica ...
http://www.aegis.org/aidsline/2000/sep/a0090538.html
File Name: a0090538.html, Size: 10KB, Last Modified: Thursday, September 28, 2000 at 8:12:04 PM
Abstract: AIMS/BACKGROUND: Many HCV RNA positive subjects with normal aminotransferase levels have significant liver damage despite normal liver biochemistry. In these patients it is not possible to discriminate between healthy carriers and subjects with chronic liver damage, unless liver biopsy is performed. The aim of this ...
http://www.aegis.org/aidsline/1999/aug/a9980287.html
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Abstract: BACKGROUND: Lamivudine is a cytosine nucleoside analogue that inhibits hepatitis B virus replication. Resistance to lamivudine monotherapy has been reported in patients who received lamivudine to prevent recurrent hepatitis B virus infection after liv ...
http://www.aegis.org/aidsline/1998/aug/m9880584.html
File Name: m9880584.html, Size: 9KB, Last Modified: Saturday, August 29, 1998 at 6:29:23 AM
Abstract: The oxidative metabolism of glutamine in HeLa cells was investigated using intact cells and isolated mitochondria. ...
http://www.aegis.org/pubs/medline/1998/jan/m9814169.html
File Name: m9814169.html, Size: 7KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
Abstract: BACKGROUND: Recently, cases of chronic hepatitis were linked to the presence of genomic sequences of a newly described RNA virus termed hepatitis G virus (HGV) and belonging to the Flaviviridae family. STUDY DESIGN AND METHODS: The presence of HGV RNA was searched for by polymerase chain reaction in a population of bl ...
http://www.aegis.org/aidsline/1997/sep/m9791266.html
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Abstract: There is limited information about the long-term efficacy of prolonged therapy (more than 6 months) with interferon alpha in hemophilic patients with chronic hepatitis C who are not coinfected with the human immunodeficiency virus (HIV-1). One hundred and seven hemophiliacs were randomly assigned to 3 million U of int ...
http://www.aegis.org/aidsline/1997/aug/m9780484.html
File Name: m9780484.html, Size: 10KB, Last Modified: Thursday, August 28, 1997 at 8:12:04 PM
Abstract: The compound 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a potent inhibitor of a number of viruses in vitro such as human immunodeficiency virus types 1 and 2, herpes simplex virus types 1 and 2, hepatitis B virus, cytomegalovirus , and Epstein-Barr virus. PMEA also proved to be e ...
http://www.aegis.org/aidsline/1997/apr/m9741270.html
File Name: m9741270.html, Size: 9KB, Last Modified: Monday, April 28, 1997 at 8:12:04 PM
Abstract: To determine the possible benefits and/or toxicities of 3TC use in HIV(+) patients known to have either chronic hepatitis B or C by monitoring serological markers. <p><b>METHODS</b>: A retrospective chart review was done on 350 HIV(+) patients receiving 3TC in the ...
http://www.aegis.org/conferences/iac/1996/tub2131.html
File Name: tub2131.html, Size: 6KB, Last Modified: Sunday, July 07, 1996 at 8:12:04 PM
Abstract: This study was undertaken to determine the prevalence of transfusion transmitted diseases (TTDs) among local blood donors, the safety offered by the four mandatory tests (for HIV, HBsAg, syphilis and malaria) and to assess alanine aminotransferase (ALT) as a surrogate test. A total of 313 blood donors were tested for ...
http://www.aegis.org/aidsline/1995/dec/m95c0169.html
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Abstract: Serum samples from 1,765 consecutive Sardinian blood donors, negative for hepatitis B surface antigen (HBsAg) and for antibodies to human immunodeficiency virus (HIV) (anti-HIV), were evaluated for the presence of antibodies to hepatitis C virus (anti-HCV) by second-generation ELISA. Anti-HCV was detected in 25 (1.45% ...
http://www.aegis.org/aidsline/1994/may/m9450017.html
File Name: m9450017.html, Size: 10KB, Last Modified: Saturday, May 28, 1994 at 8:12:04 PM
Abstract: This prospective study was carried out with the aim of evaluating the efficacy of solvent/detergent inactivation of the hepatitis C virus (HCV) as applied to a chromatographic factor VIII concentrate. In parallel, the markers for other viruses, either lipid-enveloped (human immunodeficiency virus types 1 and 2 [HIV-1 ...
http://www.aegis.org/aidsline/1994/feb/m9420218.html
File Name: m9420218.html, Size: 10KB, Last Modified: Monday, February 28, 1994 at 8:12:04 PM
Abstract: L-689,502, N-[2(R)-hydroxy-1(S)-indanyl]-5(S)-(1,1-dimethylethoxy- carbonylamino)-4(S)-hydroxy-6-phenyl-2(R)-(4-[2-(4- morpholinyl)ethoxy]phenyl)methyl hexanamide, is a potent inhibitor of human immunodeficiency virus-1 protease. The effect of dose on the elimination kinetics of L-689,502 was studied in rats and dogs. ...
http://www.aegis.org/aidsline/1993/jan/m9310643.html
File Name: m9310643.html, Size: 10KB, Last Modified: Thursday, January 28, 1993 at 8:12:04 PM
Abstract: To evaluate the factors determining the severity of chronic hepatitis B virus infection and the interactions of human immunodeficiency virus and hepatitis delta virus infections, we retrospectively analyzed 260 patients, 146 of whom were followed for a mean of 31.4 +/- 1.8 mo. Human immunodeficiency virus, hepatitis B ...
http://www.aegis.org/aidsline/1992/jul/m9270803.html
File Name: m9270803.html, Size: 10KB, Last Modified: Tuesday, July 28, 1992 at 8:12:04 PM
Abstract: <p><b>OBJECTIVE</b>: The aim of the study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis due to hepatitis B virus (HBV) infection in homosexual men.</p> <p><b>METHODS</b>: We compared 60 anti-HIV negative and 42 anti-HIV positive (27 patients with stage II or III, 15 ...
http://www.aegis.org/conferences/iac/1992/pob3464.html
File Name: pob3464.html, Size: 6KB, Last Modified: Sunday, July 19, 1992 at 8:12:04 PM
Abstract: A 33-year-old heterosexual white man underwent a liver biopsy for determination of mild elevation of aminotransferase levels (aspartate aminotransferase, two times; alanine aminotransferase, three times). The patient had acquired immunodeficiency syndrome (stage IVC2) with tuberculosis of the lymph nodes. Antibody to ...
http://www.aegis.org/aidsline/1990/nov/m90b0794.html
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Abstract: SAN DIEGO - Gilead Sciences , Inc. (Nasdaq: GILD) today announced results from ARIES-3, an open-label, single-arm, Phase III study evaluating the efficacy and safety of ambrisentan in patients with pulmonary hypertension (PH), which showed a mean 21-meter improvement from baseline in six-minute walk distance (6MWD) at ...
http://www.aegis.org/news/bw/2009/bw090532.html
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Abstract: The efficiency of heat treatment procedures of factor VIII and factor IX concentrates, prepared from voluntary, non-paid donors by three French Blood Transfusion Centres, on the inactivation of HIV and non-A, non-B hepatitis (NANB) viruses was assessed. Some 43 patients (26 haemophilia A, 17 haemophilia B) were follow ...
http://www.aegis.org/aidsline/1989/mar/m8930160.html
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Abstract: The safety of an antihaemophilic factor concentrate treated with the organic solvent tri-(n-butyl)phosphate and sodium cholate (factor VIII-SD) was assessed for transmission of non-A, non-B (NANB) hepatitis and human immunodeficiency virus (HIV). Patients enrolled in the study had no previous exposure to blood product ...
http://www.aegis.org/aidsline/1988/nov/m88b0079.html
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Abstract: Blood derived products carry the risk of virus transmission, especially for the hepatitis B virus (HBV), non-A/non-B virus(es) (NANBV) and human immunodeficiency virus (HIV). The precautionary measures for guaranteeing the virus safety of the pasteurized antithrombin III concentrate Kybernin HS/P are described and the ...
http://www.aegis.org/aidsline/1988/feb/m8820213.html
File Name: m8820213.html, Size: 9KB, Last Modified: Wednesday, January 07, 2009 at 5:15:29 AM
Abstract: ...
http://www.aegis.org/aidsline/1987/oct/m87a0206.html
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Abstract: Several groups including ours at Hyland have studied the incidence of HTLV-III/LAV seroconversion and non-A, non-B hepatitis (NANBH) in recipients of products made from unscreened plasma. Of 18 previously untreated patients who received heat-treated factor VIII concentrate (HEMOFIL T), none seroconverted for HTLV-III/ ...
http://www.aegis.org/aidsline/1987/nov/m87b0145.html
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