Your Search for anabolism matched 72 Documents (Page 1 of 3).
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Abstract: We have investigated the drug synergism between AZT and ddI in PBMC cells from pediatric patients with HIV-1 infection ex vivo and in T-cells in vitro. We investigated whether the drug anabolites, AZTTP and ddATP, could act synergistically intracellul ...
http://www.aegis.org/aidsline/1995/feb/m9521049.html
File Name: m9521049.html, Size: 10KB, Last Modified: Tuesday, February 28, 1995 at 8:12:04 PM
Abstract: Nucleoside reverse transcriptase inhibitors (NRTIs) are anabolised intracellularly to their known corresponding active triphosphate (TP). This intracellular anabolism plays a critical role regarding both their efficacy and toxicity. ...
http://www.aegis.org/conferences/hiv-glasgow/2002/pl8-3.html
File Name: pl8-3.html, Size: 8KB, Last Modified: Sunday, November 17, 2002 at 8:12:04 PM
Abstract: The anabolism of 1592U89, 1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cycl- o pentene-1-methanol, a selective inhibitor of human immunodeficiency virus (HIV), was characterized in human T-lymphoblastoid CD4+ CEM cells. 1592U89 was ultimately anabolized to the triphosphate (TP) of the guanine analog carbovi ...
http://www.aegis.org/aidsline/1997/oct/m97a0391.html
File Name: m97a0391.html, Size: 9KB, Last Modified: Tuesday, October 28, 1997 at 8:12:04 PM
Abstract: <p><b>BACKGROUND:</b> SPD-756, a new purine analogue, has promising efficacy against wild type and drug-resistant strains of HIV-1 without apparent in vitro toxicity. Resistance to SPD-756 emerges slowly in vitro and the variants show low resistance to SPD-756 and to other marketed nucleoside analogues. Nucleoside an ...
http://www.aegis.org/conferences/iac/2002/mopea3008.html
File Name: mopea3008.html, Size: 7KB, Last Modified: Monday, July 08, 2002 at 6:29:23 AM
Abstract: BACKGROUND: Highly active antiretroviral therapy (HAART) resulting in maximal suppression of viral load (VL) is believed to have eliminated loss of Body Cell Mass (BCM) leading to wasting. BCM is protoplasmic tissue necessary for glucose oxidation, protein synthesis, and immune system function. Catabolism of BCM corre ...
http://www.aegis.org/aidsline/1998/dec/m98c0974.html
File Name: m98c0974.html, Size: 9KB, Last Modified: Tuesday, December 29, 1998 at 6:29:23 AM
Abstract: <p><b>BACKGROUND:</b> Highly active antiretroviral therapy (HAART) resulting in maximal suppression of viral load (VL) is believed to have eliminated loss of Body Cell Mass (BCM) leading to wasting. BCM is protoplasmic tissue necessary for glucose oxidation, protein synthesis, and immune system function. Catabolism o ...
http://www.aegis.org/conferences/iac/1998/60517.html
File Name: 60517.html, Size: 7KB, Last Modified: Sunday, June 28, 1998 at 8:12:04 PM
Abstract: The T-cell line Jurkat E6-1 was rendered resistant to zidovudine ( AZT ) in vitro by exposure to low but gradually increased concentrations of the drug. Biochemical pharmacology studies of [3H]AZT in the AZT-resistant T-cell lines showed a significant r ...
http://www.aegis.org/aidsline/1996/apr/m9640244.html
File Name: m9640244.html, Size: 10KB, Last Modified: Sunday, April 28, 1996 at 8:12:04 PM
Abstract: 3 -Azido-3 -deoxythymidine ( AZT ) is HIV-inhibitory in human macrophages, which is surprising in view of the low AZT phosphorylation reported in macrophage extracts. To elucidate the mechanism of AZT activation, we studied AZT anabolism as well as cata ...
http://www.aegis.org/aidsline/1992/sep/m9290649.html
File Name: m9290649.html, Size: 10KB, Last Modified: Monday, September 28, 1992 at 8:12:04 PM
Abstract: Chronic exposure of H9 cells to 25 microM zidovudine (H9- AZT cells) causes a 2- to 3-fold increase in thymidine kinase (TK) activity (Agarwal RP, Int J Purines Pyrimidine Res, in press). The present study compared thymidine (TdR) and AZT anabolism in ...
http://www.aegis.org/aidsline/1991/nov/m91b0557.html
File Name: m91b0557.html, Size: 10KB, Last Modified: Thursday, November 28, 1991 at 8:12:04 PM
Abstract: Possible therapeutic interventions can be based on the emerging knowledge of the life cycle of the human immunodeficiency virus that causes AIDS and its related disorders. The characteristics of HIV as a retrovirus (cell binding and entry, integration, latency and reactivation, and protein production and assembly) are ...
http://www.aegis.org/aidsline/1989/may/m8950669.html
File Name: m8950669.html, Size: 10KB, Last Modified: Wednesday, January 07, 2009 at 5:28:27 AM
Abstract: 2 ,3 -Dideoxyinosine (ddlno) is a potent and selective inhibitor of human immunodeficiency virus in human lymphoid cells and monocytes/macrophages. Earlier studies [J. Biol. Chem. 263:15354 (1988)] showed that anabolism of ddlno in human lymphoid cells is mediated via an initial step of phosphorylation and subsequent ...
http://www.aegis.org/aidsline/1989/dec/m89c0142.html
File Name: m89c0142.html, Size: 10KB, Last Modified: Wednesday, January 07, 2009 at 5:23:32 AM
Abstract: A series of 2 ,3 -didehydro-2 ,3 -dideoxyribonucleosides (ddeNs) [i.e., 2 ,3 -dideoxythymidinene (ddeThd), 2 ,3 -dideoxyuridinene (ddeUrd), 2 ,3 -dideoxycytidinene (ddeCyd), and 2 ,3 -dideoxyadenosinene (ddeAdo)] has been synthesized and the individual members compared in terms of their in vitro antiviral, antimetabol ...
http://www.aegis.org/aidsline/1987/oct/m87a0266.html
File Name: m87a0266.html, Size: 11KB, Last Modified: Wednesday, January 07, 2009 at 5:06:03 AM
Abstract: The thymidine analog 3 -azido-3 -deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV) replication effectively in the 50-500 nM range [Mitsuya, H., Weinhold, K. J., Furman, P. A., St. Clair, M. H., Nusinoff-Lehrman, S., Gallo, R. C., Bolognesi, D., Barry, D. W. & Broder, S. (1985) ...
http://www.aegis.org/aidsline/1987/feb/m8720116.html
File Name: m8720116.html, Size: 11KB, Last Modified: Wednesday, January 07, 2009 at 5:03:33 AM
Abstract: The combination of tenofovir and emtricitabine produced synergistic anti-HIV activity in vitro and this activity correlated with increased levels of intracellular phosphorylation observed for the drugs in combination. These results support the use of these drugs as a dual NRTI backbone in combination therapy for the tr ...
http://www.aegis.org/conferences/iashivpt/2005/wepe3-3c05.html
File Name: wepe3-3c05.html, Size: 9KB, Last Modified: Monday, July 25, 2005 at 6:29:23 AM
Abstract: BACKGROUND: SPD754 is a cytidine analogue with promising efficacy over 10 days monotherapy. Cytidine analogues share common pathways for absorption, excretion and in their intracellular anabolism. This study aimed to investigate the plasma pharmacokinetic (PK) profiles of SPD754 and ...
http://www.aegis.org/conferences/iac/2004/tupeb4625.html
File Name: tupeb4625.html, Size: 6KB, Last Modified: Monday, July 12, 2004 at 6:29:23 AM
Abstract: BACKGROUND: SPD754 is a deoxycytidine analogue with promising clinical efficacy against HIV-1 infection. Antiretroviral deoxycytidine analogues are substrates for deoxycytidine kinase and may therefore compete with each other for intracellular phosphorylation. SPD754 does not inhibit the phosphorylation of ...
http://www.aegis.org/conferences/iac/2004/tupeb4622.html
File Name: tupeb4622.html, Size: 6KB, Last Modified: Monday, July 12, 2004 at 6:29:23 AM
Abstract: Oxymetholone was found to have true anabolic effects in a double-blind, placebo-controlled phase III trial. The BID (100 mg/d) regimen appeared equally effective to TID (150 mg/d) dosing while displaying reduced liver toxicity. Due to its favourable protein anabolism, it may be recommended for therapy of wasting and li ...
http://www.aegis.org/conferences/hiv-glasgow/2002/p144.html
File Name: p144.html, Size: 6KB, Last Modified: Sunday, November 17, 2002 at 8:12:04 PM
Abstract: BACKGROUND: Although HAART has greatly impacted treatment of HIV infection, lipodystrophy and HIV wasting still represent unresolved problems in HIV therapy and patient care. Oxymetholone, a testosterone derivative, has been shown to promote weight gain in AIDS-associated wasting. METHODS: We analyzed the effects of ox ...
http://www.aegis.org/conferences/croi/2002/705-t.html
File Name: 705-t.html, Size: 6KB, Last Modified: Sunday, February 24, 2002 at 8:12:04 PM
Abstract: Oxymetholone was found to have true anabolic effects in a double-blind, placebo-controlled Phase III trial. The twice daily (100 mg/day) regimen appeared equally effective to three times daily (150 mg/day) dosing while displaying reduced liver toxicity. Due to its favorable protein anabolism, it may be recommended for ...
http://www.aegis.org/conferences/lipo/2001/70.html
File Name: 70.html, Size: 6KB, Last Modified: Wednesday, October 24, 2001 at 6:29:23 AM
Abstract: The evaluation of the antiviral activity of a series of 2- hydroxylmethylcyclopropylidenemethyl purines and pyrimidines revealed that the Z-isomers of the adenine (Z-Ade) and guanine (Z-Gua) analogs were potent inhibitors of HCMV replication in vitro. The HCMV reference strains AD169 and Towne had an ID50 of 2 micromo ...
http://www.aegis.org/aidsline/2000/may/a0050452.html
File Name: a0050452.html, Size: 10KB, Last Modified: Sunday, May 28, 2000 at 8:12:04 PM
Abstract: CONTEXT: Repletion of lean body mass (LBM) that patients lose in human immunodeficiency virus (HIV) infection has proved difficult. In healthy, HIV-seronegative men, synergy between progressive resistance exercise (PRE) and very high-dose testosterone therapy has been reported for gains in LBM and muscle strength. OBJ ...
http://www.aegis.org/aidsline/1999/jun/a9960062.html
File Name: a9960062.html, Size: 12KB, Last Modified: Monday, June 28, 1999 at 8:12:04 PM
Abstract: OBJECTIVES: To quantitatively investigate the biological role of mutations in the human cytomegalovirus UL97 encoded phosphotransferase detected in ganciclovir-resistant HCMV strains recovered from AIDS patients. METHODS: Vaccinia virus recombinants (rVV) expressing HCMV UL97 genes ...
http://www.aegis.org/aidsline/1998/dec/m98c3818.html
File Name: m98c3818.html, Size: 11KB, Last Modified: Tuesday, December 29, 1998 at 6:29:23 AM
Abstract: INTRODUCTION: Dorsocervical fat pad enlargement (buffalo hump) associated with truncal obesity and peripheral lipodystrophy and hypertriglyceridemia, often associated with lean body mass wasting has been described in HIV positive patients maintained on highly active antiretroviral therapy (HAART) including ...
http://www.aegis.org/aidsline/1998/dec/m98c3730.html
File Name: m98c3730.html, Size: 11KB, Last Modified: Tuesday, December 29, 1998 at 6:29:23 AM
Abstract: PMPA is an acyclic nucleotide analog with marked efficacy in the prevention of SIV infection in rhesus macaques (Tsai et al, Science 270:1197). Moreover, treatment of chronically infected SIV macaques resulted in 2-3-log reduction in SIV RNA. To increase the low oral bioavailability of PMPA, a prodrug, bis isopropylox ...
http://www.aegis.org/aidsline/1998/jun/m9860302.html
File Name: m9860302.html, Size: 9KB, Last Modified: Monday, June 29, 1998 at 6:29:23 AM
Abstract: <p><b>OBJECTIVES:</b> To quantitatively investigate the biological role of mutations in the human cytomegalovirus UL97 encoded phosphotransferase detected in ganciclovir-resistant HCMV strains recovered from AIDS patients. </p> <p><b>METHODS:</b> Vaccinia virus recombinants (rVV) expressing HCMV UL97 genes carrying ...
http://www.aegis.org/conferences/iac/1998/31199.html
File Name: 31199.html, Size: 8KB, Last Modified: Sunday, June 28, 1998 at 8:12:04 PM
Abstract: INTRODUCTION: Dorsocervical fat pad enlargement (buffalo hump) associated with truncal obesity and peripheral lipodystrophy and hypertriglyceridemia, often associated with lean body mass wasting has been described in HIV positive patients maintained on highly active antiretroviral therapy (HAART) including ...
http://www.aegis.org/conferences/iac/1998/32164.html
File Name: 32164.html, Size: 8KB, Last Modified: Sunday, June 28, 1998 at 8:12:04 PM
Abstract: New treatment methods are being developed to help prevent or reverse the effects of disease-associated wasting. The wasting, known as cachexia, often occurs in patients with chronic and infectious diseases, including cancer, tuberculosis, and HIV/AIDS. A patient with cachexia will have an increase in their metabolism, ...
http://www.aegis.org/news/ads/1998/ad980777.html
File Name: ad980777.html, Size: 10KB, Last Modified: Thursday, May 07, 1998 at 3:00:00 PM
Abstract: PMPA is an acyclic nucleotide analog with marked efficacy in the prevention of SIV infection in rhesus macaques (Tsai et al, Science 270:1197). Moreover, treatment of chronically infected SIV macaques resulted in 2-3-log reduction in SIV RNA. To increase the low oral bioavailability of PMPA, a prodrug, bis (isopropylox ...
http://www.aegis.org/conferences/croi/1998/630.html
File Name: 630.html, Size: 5KB, Last Modified: Sunday, February 01, 1998 at 8:12:04 PM
Abstract: This study examined cellular and vascular changes in gingival connective tissue samples by stereologic point-counting procedure ...
http://www.aegis.org/pubs/medline/1998/jan/m9812758.html
File Name: m9812758.html, Size: 6KB, Last Modified: Saturday, January 31, 1998 at 10:00:00 PM
Abstract: Thalidomide therapy has been shown to cause increases in body weight in patients with HIV and tuberculosis infections. To examine the nature of this weight gain and its immunological correlates in patients with HIV infection, we studied a cohort of 13 patients with minimally symptomatic HIV disease. Patients were admi ...
http://www.aegis.org/aidsline/1997/dec/m97c0647.html
File Name: m97c0647.html, Size: 9KB, Last Modified: Sunday, December 28, 1997 at 8:12:04 PM